Vivostat® Co-Delivery
slow release of substance
Vivostat® Co-Delivery
The opportunities with the Vivostat® Co-Delivery system are vast and the system allows the surgeon to apply a selected substance easily and effectively. Furthermore, it may be possible to reduce the total cost of a procedure by using the Vivostat® Co-Delivery system2.
Options for co-delivery include:
drugs
- Antimicrobials
- Chemotherapeutics
- Pain medications
cells
- Stem cells
- Skin cells
Products characteristics
Benefits Vivostat® Co-Delivery
Co-applying drugs, cells etc. with a Vivostat® sealant or matrix solution offers the surgeon and the patient a number of benefits:
- Topical application
- Targeting affected/desired area
- Possible higher local dose
- Possible lower systemic impact
- Improved compliance
how does the co-delivery system work?
When you co-deliver, you can apply up to 5 ml of substance with the sealant/matrix solution.
The substance is applied using the Vivostat® Spraypen or endoscopic solution which enables the surgeon to apply the substance accurately and intermittently throughout the entire procedure.
The substance and the sealant or matrix solution is mixed once it leaves the tip of the application device and polymerizes immediately upon application – this way the substances stay where they are intended to act.
FAQ - Vivostat® Co-delivery
We have gathered the most frequently asked questions about Vivostat® Co-Delivery.
If you have any other questions, you are always welcome to contact your local distributor or Vivostat.
The substance volume may be too high or the pH level may be above 7.
We have in some circumstances experienced no polymerization with:
- Cefepim
- Clindamycin/Dalacin
- Cubicin
- Ertapenem6
We have great experience with good polymerization using:
- Amikacin6
- Augmentin
- Bacitracin (Baneocin)
- Biklin
- Cefrom
- Ciprofloxacin
- Ciprofloxacin + Colistin
- Colistin (Promixin)
- Flucloxacillin
- Gentamycon
- Penem – certain kinds
- Tazobactam (Piperacillin/Tazonam)
- Teicoplanin6
- Tobramycin (Nebcina)
- Tobramycin + Colistin
- Unasyn (Ampicillin/Sulbactam6)
- Vancomycon
The list might not be complete.
PRODUCT order codes vivostat® Co-Delivery
Vivostat® PRF Set – Co-Delivery
Contact your local distributor for more details.
Vivostat® Spraypen Kit – Co-Delivery
Contact your local distributor for more details.
Vivostat® Endoscopic Kit – Co-Delivery
Contact your local distributor for more details.
Processor Unit
Needed to prepare the product.
Contact your local distributor for more details.
Applicator Unit – Co-Delivery
Needed to co-apply other substances with the product.
Contact your local distributor for more details.
Foot Switch
To be used with APL 404. Always needed for Co-Delivery.
Contact your local distributor for more details.
Vivostat® Split Kit
To be used if you need to freeze the sealant/matrix solution with the intention to treat the patient more than one time from one blood donation.
Contact your local distributor for more details.
Application devices
The Vivostat® System offers a variety of different disposable application devices as well as a number of reusable handles.
Vivostat® System
Using the Vivostat® System, you can prepare autologous platelets enriched fibrin with multiple growth factors embedded in a matrix.
- The amount of substance and its effect on the patient is always the responsibility of the surgeon.
- Vadalà, G., Di Martino, A., Tirindelli, M. C., Denaro, L., & Denaro, V. (2008), Use of autologous bone marrow cells concentrate enriched with platelet-rich fibrin on corticocancellous bone allograft for posterolateral multilevel cervical fusion, Journal of tissue engineering and regenerative medicine, 2(8), 515–520, https://doi.org/10.1002/term.121
- Gugerell, A., Schossleitner, K., Wolbank, S., Nürnberger, S., Redl, H., Gulle, H., Goppelt, A., Bittner, M., & Pasteiner, W. (2012). High thrombin concentrations in fibrin sealants induce apoptosis in human keratinocytes. Journal of Biomedical Materials Research Part A, 100A(5), 1239–1247. https://doi.org/10.1002/jbm.a.34007
- Lardinois, D., Jung, F., Opitz, I., Rentsch, K., Latkoczy, C., Vuong, V., Varga, Z., Rousson, V., Günther, D., Bodis, S., Stahel, R. A., & Weder, W. (2006b). Intrapleural topical application of cisplatin with the surgical carrier Vivostat increases the local drug concentration in an immune-competent rat model with malignant pleuromesothelioma. The Journal of Thoracic and Cardiovascular Surgery, 131(3), 697-703.e3. https://doi.org/10.1016/j.jtcvs.2005.08.012
- Knafl, D., Thalhammer, F., & Vossen, M. G. (2017), In-vitro release pharmacokinetics of amikacin teicoplanin and polyhexanide in a platelet rich fibrin layer (PRF) a laboratory evaluation of a modern, autologous wound treatment, PLoS One e, 12(7), e0181090, https://doi.org/10.1371/journal.pone.0181090
- Vivostat® Co-Delivery: Antibiotics experienced use (2024, March 11). Medical University of Vienna http://vivostat.com/Vivostat-Co-Delivery-Antibiotics-experienced-use