Vivostat® solutions have been used by urologists for years and have proven invaluable when a haemostat, a sealant or a tissue regenerating solution has been necessary in urology. The Vivostat® System can accommodate various types of surgery (open surgery, endoscopy, laparoscopy and robotics) and is used for many different surgical procedures including:

  • Partial nephrectomy
  • Radical prostatectomy
  • Kidney transplantation
  • Pyelo-plastic operation
  • Cystectomy
  • Bladder hemorrhagic episodes
  • Pelvic organ prolapse
  • Pelvic organ mesh removal
  • Ureter anastomosis

Despite continuous advances in surgical techniques and solutions in urology, challenges persist. Vivostat® meet these challenges, offering solutions for:

  • Haemostasis of bleedings
  • Sealing suture lines
  • Reducing drainage and preventing seroma formation
  • Tissue regeneration

Vivostat® provides surgeons with a choice of two remarkable products to address these challenges effectively.

If haemostasis and/or sealing are the primary challenges, Vivostat® Fibrin is an excellent choice. When tissue regeneration is paramount, Vivostat® PRF stands as the optimal choice.

main advantages using vivostat®


Vivostat® in urology

Click on the video and see the Vivostat® System in use in urological surgery.

Vivostat® Co-Delivery

The revolutionary system makes it possible to co-apply e.g. stem cells or antibiotics with the Vivostat® product.

Vivostat® PRF

Using the Vivostat® System, you can prepare autologous platelets with multiple growth factors embedded in a matrix. 

Schips, L., Dalpiaz, O., Cestari, A., Lipsky, K., Gidaro, S., Zigeuner, R., & Petritsch, P. (2006), Autologous fibrin glue using the Vivostat System for hemostasis in laparoscopic partial nephrectomy, European Euology, 50(4), 801–805, https://doi.org/10.1016/j.eururo.2006.03.010

Tirindelli, M. C., Flammia, G., Sergi, F., Cerretti, R., Cudillo, L., Picardi, A., Postorino, M., Annibali, O., Greco, R., Avvisati, G., & Arcese, W. (2009), Fibrin glue for refractory hemorrhagic cystitis after unrelated marrow, cord blood, and haploidentical hematopoietic stem cell transplantation, Transfusion, 49(1), 170–175, https://doi.org/10.1111/j.1537-2995.2008.01934.x

Gidaro, S., Cindolo, L., Lipsky, K., Zigeuner, R., & Schips, L. (2009), Efficacy and safety of the haemostasis achieved by Vivostat System during laparoscopic partial nephrectomy, Archivio italiano di urologia, 81(4), 223–227, https://pubmed.ncbi.nlm.nih.gov/20608146/

Marszalek, M., Chromecki, T., Al‐Ali, B. M., Meixl, H., Madersbacher, S., Jeschke, K. N., Pummer, K., & Zigeuner, R. (2011), Laparoscopic partial nephrectomy: a matched-pair comparison of the transperitoneal versus the retroperitoneal approach, Journal Urology, 77(1), 109–113, https://doi.org/10.1016/j.urology.2010.02.057

Gorlero, F., Glorio, M., Lorenzi, P., Bruno-Franco, M., & Mazzei, C. (2012), New approach in vaginal prolapse repair mini invasive surgery associated with application of platelet-rich fibrin, Internation Urogynecology Journal, 23(6), 715–722, https://doi.org/10.1007/s00192-012-1667-5

Hevia, M., Junquera, J. A., Sacristán, R., Rodríguez, J., Lobo, B. L., Méndez, S., Pellejero, P., & Abascal-García, R. (2013), Haemostasis control during laparoscopic partial nephrectomy without parenchymal renorrhaphy: the Vivostat experience, Actas Urológicas Españolas, 37(1), 47–53, https://doi.org/10.1016/j.acuro.2012.03.014

Tirindelli, M. C., Flammia, G., Bove, P., Cerretti, R., Cudillo, L., De Angelis, G., Picardi, A., Annibali, O., Nobile, C., Cerchiara, E., Dentamaro, T., De Fabritiis, P., Lanti, A., Ferraro, A., Sergi, F., Di Piazza, F., Avvisati, G., & Arcese, W. (2014), Fibrin glue therapy for severe hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation, Biology of Blood and Marrow Transplantation, 20(10), 1612–1617, https://doi.org/10.1016/j.bbmt.2014.06.018

Chan, E. S., Yee, C., Chiu, P. K., Chan, C. M., Tam, M. H., & Ng, C. (2016), Effects of an autologous fibrin sealant on lymphatic leakage after radical cystectomy: A matched case-control study, Surgical Practice, 20(3), 119–123,  https://doi.org/10.1111/1744-1633.12189

Bove, P., Iacovelli, V., Tirindelli, M. C., Bianchi, D., Flammia, G., Cipriani, C., Ferraro, A., Ferro, M., Arcese, W., Ingrosso, G., Vespasiani, G., & Agrò, E. F. (2019), Endoscopic intravesical fibrin glue application in the treatment of refractory hemorragic radiation cystitis – a single cohort pilot study, Journal of Endourology, 33(2), 93-98, https://doi.org/10.1089/end.2018.0028

Garayev, A., Aytaç, Ö., Tavukçu, H. H., & Atuğ, F. (2019), Effect of autologous fibrin glue on lymphatic drainage and lymphocele formation in extended bilateral pelvic lymphadenectomy in robot-assisted radical prostatectomy, Journal of Endourology, 33(9), 761–766, https://doi.org/10.1089/end.2018.0853

Pino, A., Frattini, F., Sun, H., Zhang, D., Wu, C., Kim, H. Y., & Dionigi, G. (2021), Use of Vivostat autologous fibrin sealant in thyroid surgery, Surgical Technology International, 18(2), 75-79, https://doi.org/10.52198/21.sti.38.so1441

Cassani, A., Marchioni, M., Silletta, F., D’Orta, C., Primiceri, G., Rizzoli, A., Di Gregorio, P., Verna, S., Natale, A., Santarone, S., Berardinelli, F., & Schips, L. (2021), Efficacy and safety of intravesical fibrin glue instillation for management of patients with refractory hemorrhagic cystitis: 12-months results. A promising therapy for hemorrhagic cystitis, Archivio Italiano di Urologia e Andrologia, 93(2), 200–205, https://doi.org/10.4081/aiua.2021.2.200