ArthroZheal®

autologous bioactive matrix

ArthroZheal® for orthopaedic surgery

With ArthroZheal® the overall orthopaedic surgery experience is transformed for patients and their surgeons while its bioactive and biocompatible properties successfully provide supportive effects for sealing, healing and regeneration of ligaments, tendons and cartilage.

Provides fast sealing and hemostasis1,3

ArthroZheal® induces immediate polymerization and great adhesion – remaining where applied even on vertical and moist surfaces2 – supporting positioning of grafts. Furthermore, ArthroZheal® improves control of bleeding and reduces hemarthrosis3. Thirdly, ArthroZheal® may offer control of potential contamination through its anti-inflammatory and antimicrobial platelet properties4-6.

Supports regeneration and healing of ligaments, tendons, menisci, cartilage and bone

Through a combination of fibrin matrix and a sustained release of high concentrations of growth factors ArthroZheal®improves regeneration and healing of tissue (cartilage, ligaments, menisci, tendons and bone) and support osteo-ligamentization, osteo-integration and graft maturation3.

Easy to apply - also during arthroscopy with saline inside the joint cavity

ArthroZheal® is easy to apply – even in water environment and can be used during arthroscopy with saline inside the joint cavity. It is the only product with immediate polymerization both in dry and in the water/saline environment. 

Vivostat® also offers a reusable arthroscopic handle, which is specifically designed with and for orthopaedic surgeons.

BENEFITS OF ARTHROZHEAL®

Sealing

Healing & regeneration

Vivostat Application Devices icon

Easy application

Play Video about People running - ArthroZheal® - Autologous bioactive matrix from Vivostat® can be used in orthopaedic surgery

give back freedom

By transforming the overall orthopaedic surgery experience for patients and their surgeons, ArthroZheal® provides a platform for fast recovery. Click on the video to see ArthroZheal® application.

Product order codes ArthroZheal®

Vivostat® Co-Delivery

The revolutionary system makes it possible to co-apply e.g. stem cells or antibiotics with the Vivostat® product.

Orthopaedic surgery

The Vivostat® System has been used in orthopaedic surgery with great success for decades,

  1. Skarpas, G. A. (2022), Arthrozheal, a bioactive fibrin scaffold for joint cartilage, tendon and soft tissue lesions. Latest results and application perspectives, Surg Technol Int sti, 41, 1636, https://doi.org/10.52198/22.sti.41.os1636
  2. Kjaergard, H. K., Velada, J. L., Pedersen, J. H., Fleron, H., & Hollingsbee, D. (2000), Comparative kinetics of polymerisation of three fibrin sealant and influence on thiming of tissue adhesion, Thrombosis Research  , 98(2), 221–228, https://doi.org/10.1016/s0049-3848(99)00234-0
  3. Beyzadeoğlu, T., Pehlivanoğlu, T., Yıldırım, K., Buldu, H., Tandoğan, R. N., & Tüzün, Ü.  (2020), Does the application of platelet-rich fibrin in anterior cruciate ligament reconstruction enhance graft healing and maturation? A comparative MRI study of 44 cases, Orthopaedic Journal Sports Medicine, 8(2), 232596712090201, https://doi.org/10.1177/2325967120902013
  4. Bayer, A., Lammel, J., Rademacher, F., Groß, J., Siggelkow, M., Lippross, S., Klüter, T., Varoga, D., Tohidnezhad, M., Pufe, T., Cremer, J., Gläser, R., & Harder, J. (2016), Platelet-released growth factors induce the antimicrobial peptide human beta-defensin- 2 in primary keratinocytes, Experimental Dermatology, 25(6), 460–465, https://doi.org/10.1111/exd.12966
  5. Knafl, D., Thalhammer, F., & Vossen, M. G.  (2017), In-vitro release pharmacokinetics of amikacin teicoplanin and polyhexanide in a platelet rich fibrin layer (PRF) a laboratory evaluation of a modern, autologous wound treatment, PLoS One e, 12(7), e0181090, https://doi.org/10.1371/journal.pone.0181090
  6. Tohidnezhad, M., Varoga, D., Podschun, R., Wruck, C. J., Seekamp, A., Brandenburg, L., Pufe, T., & Lippross, S. (2011). Thrombocytes are effectors of the innate immune system releasing human beta defensin-3. Injury-International Journal of the Care of the Injured, 42(7), 682–686. https://doi.org/10.1016/j.injury.2010.12.010