The Vivostat® System is used in neurosurgery globally. The uniqueness of the application devices combined with the sealant/matrix physical properties makes it a match for surgeries related to the brain and nerves.

The Vivostat® application devices come with the possibility to control the delivery of the product including a “No Air” mode, which have very low impact on the tissue and vital organs/nerves in the skull. Combined with the extreme accuracy and precision spraying this mode is perfect for neurosurgery.

Neurosurgeons most often use the Vivostat® Fibrin or Vivostat® PRF for:

  • Open cranium procedures
  • Transsphenoidal (transnasal) surgery’
  • Dural closure/CSF leakages
  • Dural defects repair
  • Spine reconstructions
  • Chiari
  • Nerve anastomoses

One of the main challenges in neurosurgery is cerebrospinal fluid (CSF) leakage. Autologous Vivostat® Fibrin and Vivostat® PRF products are optimal solutions for reduction of CSF leaks. Managing CSF leakages pro-actively can help reduce complications and contain the total cost of the treatment.

In transsphenoidal procedures Vivostat® PRF is used for sealing the dura, sealing and regeneration of sphenoidal bone and cover the sinus area, lowering post-op bleedings and infections.

main advantages using vivostat®

Vivostat® Fibrin: autologous fibrin outperforming other fibrin sealants in key parameters such as polymerization, elasticity, adhesion, and its impact on tissue.

Vivostat® PRF: cutting-edge autologous platelet rich fibrin matrix, functioning as both a haemostat/sealant and a supportive agent for tissue repair.

Vivostat® for use in neurosurgery

Vivostat® in neurosurgery

Click on the video and see the Vivostat® System in use in neurosurgery.

Vivostat® Fibrin

Our autologous fibrin show best-in-market results on parameters such as time to haemostasis, elasticity, adhesion to and impact on tissue. 

Vivostat® PRF

Using the Vivostat® System, you can prepare autologous platelets with multiple growth factors embedded in a matrix. 

Poulsgaard, L., Mørck, A., & Holm, N. (2007). A safety study of the use of VivoStat® Patient-Derived fibrin sealant containing tranexamic acid in neurosurgery. Skull Base, 17(S 2).

Bovenzi, D., et al. (2007). Use of autologous fibrin adhesive in neurosurgery. Presented at SIDEM (Società Italiano di Emaferesi e Manipollazione Cellulare).

Yıldırım, A. E., Dursun, E., Özdöl, Ç., Divanlıoğlu, D., Nacar, O. A., Koyun, O. K., Ilmaz, A. E., & Belen, A. D. (2013). Using an autologous fibrin sealant in the preventing of cerebrospinal fluid leak with large skull base defect following endoscopic endonasal transsphenoidal surgery. Turkish Neurosurgery.

Tomazic, P. V., Edlinger, S., Gellner, V., Koele, W., Gerstenberger, C., Braun, H., Mokry, M., & Stammberger, H. R. (2014). Vivostat®: an autologous fibrin sealant as useful adjunct in endoscopic transnasal CSF-leak repair. European Archives of Oto-Rhino-Laryngology, 272(6), 1423–1427.

Graziano, F., Certo, F., Basile, L., Maugeri, R., Grasso, G., Meccio, F., Ganau, M., & Iacopino, D. G. (2015), Autologous fibrin sealant (Vivostat) in the neurosurgical practice: Part I: Intracranial surgical procedure, Surgical Neurology International, 6(1), 77,

Graziano, F., Maugeri, R., Basile, L., Meccio, F., & Iacopino, D. G. (2016), Aulogous fibrin sealant (Vivostat) in the neurosurgical practice: Part II: Vertebro-spinal procedures, Surgical Neurology International, 7(4), 77,

Baptista, P. M., Fernández, S., Bejarano, B., & Manrique, R. (n.d.). Use of fibrin sealant (Vivostat®) in skull base surgery.