Obsidian® ASG
anastomoses safeguard
Obsidian ASG
Obsidian® ASG – Anastomoses SafeGuard, a breakthrough in regenerative surgery serves as an anastomotic reinforcement, supplementing standard closing techniques after resection surgery in the gastrointestinal tract. It not only effectively seals and heals anastomoses, but also harnesses the body’s own regenerative capabilities to promote fast and effective healing, improving the overall recovery process.
- Application of Obsidian® ASG following colorectal resection is related to a low rate of anastomotic leakages – 2.3%
(6/261 patients)1 - Application of Obsidian® ASG in colorectal resection is safe for patients undergoing gastrointestinal resection and
related to a low rate of postoperative complications1
- Efficient air and liquid tight anastomosis sealing1
- Immediate polymerization and adhesion to tissue – even when applied on vertical, inverted or moist surfaces6
- Obsidian® ASG is highly elastic and conformable to movement – high mechanical protection and anastomotic burst pressure immediately after application1,2
- Acts as a source of angiogenic growth factors supporting tissue proliferation and growth of new blood vessels1,2
- Can be used for staple line bleeding
benefits of obsidian® asg
- Is related to a low risk of anastomotic leaks1
- Effectively seals anastomoses1,2
- Improves anastomotic tissue healing1,2
- High mechanical protection and anastomotic burst pressure1,2
- Antimicrobial properties3-5
- Can be used for staple line bleeding
Resection surgery in the gastrointestinal tract is a common treatment of colorectal cancer, inflammatory bowel diseases and esophageal cancer. The most dreaded and devastating surgical complication following resection surgery is anastomotic leak, as this leads to increased morbidity, mortality, days in hospital and costs as well as impaired patient QoL.1,7
Current rates of anastomotic leaks following resection vary depending on anatomic site:
- Colon: 4%8
- Rectum: 10%8
- Esophagus: 10%9
- Patients experiencing an anastomotic leak have increased risk of significant morbidity10
- Patients experiencing anastomotic leak have increased risk of mortality – 30-day mortality rate for patients experiencing an anastomotic leak is 10.6% versus 1.6% for patients with no an intact anastomosis11
obsidian® asg – easy to apply
- Obsidian® ASG is easy to apply accurately
- Compatible application devices and different spray modes offer a solution for various types of surgery (open surgery, endoscopy, laparoscopy, robotics)
- The intra- and extra-anastomotic application technique sustains the sealing and healing of anastomoses
obsidian® ASG serves as a multi-level anastomoses safeguard
The photo shows the intra-anastomotically applied Obsidian® ASG providing bioactive sealing and enhancing anastomotic tissue healing.
This photo is taken through a microscope and shows how Obsidian® ASG covers the titanium clamps and acts as a staple line reinforcement.
The arrows point to the anastomotic site and show the anastomotic tissue healing on day 30 in a porcine study2
Play Video
Properties of obsidian®
Click on the video and see the amazing showcase of the application of Obsidian® ASG following deep anterior rectum resection.
obsidian® ASG is designed to be a cost-effective solution for anastomotic procedures1
- Anastomotic leak increases length of stay in hospital12
- Costs associated with a patient experiencing anastomotic leak are up to 4 times higher than those incurred by a patient with no surgical complications12
Improve patient safety
Reduce reoperations
Reduce days in hospital
Product order codes obsidian® ASG
GM 720
GM 220
PRO 800
APL 400
APL 404
VS 222
VS 510
GM 720
Obsidian® ASG Set
To be used together with GM 220. Application to be controlled with VS 222.
Contact your local distributor for more details.
GM 220
Obsidian® ASG Endoscopic Applicator Handle
Reusable handle for endoscopic use. Application to be controlled with VS 222.
Contact your local distributor for more details.
PRO 800
Processor Unit
Needed to prepare the product.
Contact your local distributor for more details.
APL 400
Applicator Unit
Needed to apply the product.
Contact your local distributor for more details.
APL 404
Applicator Unit – Co-Delivery
Needed to apply co-deliver other substances with the product.
Contact your local distributor for more details.
VS 222
Foot Switch
To be used with APL 400/404.
Contact your local distributor for more details.
VS 510
Vivostat® Split Kit
To be used if you need to freeze the sealant/matrix solution with the intention to treat the patient more than one time from one blood donation.
Contact your local distributor for more details.
Application devices
The Vivostat® System offers a variety of different disposable application devices as well as a number of reusable handles.
General surgery
The ability to use the Vivostat® Endoscopic Applicator in general surgery has proven very useful.
- Shamiyeh, A., Klugsberger, B., Aigner, C., Schimetta, W., Herbst, F., & Dauser, B. (2021), Obsidian ASG autologous platelet-rich fibrin matrix and colorectal anastomotic healing – a preliminary study, Surgical Technology International, 39, 147-154, https://doi.org/10.52198/21.sti.39.cr11508
- Dauser, B., Heitland, W., Bader, F. G., Brunner, W., Nir, Y., & Zbar, A. P. (2019), Histologic changes in early colonic anastomotic healing using autologous platelet-rich fibrinmatrix, European Surgery, 52(4), 155-164, https://doi.org/10.1007/s10353-019-0578-9
- Bayer, A., Lammel, J., Rademacher, F., Groß, J., Siggelkow, M., Lippross, S., Klüter, T., Varoga, D., Tohidnezhad, M., Pufe, T., Cremer, J., Gläser, R., & Harder, J. (2016), Platelet-released growth factors induce the antimicrobial peptide human beta-defensin- 2 in primary keratinocytes, Experimental Dermatology, 25(6), 460–465, https://doi.org/10.1111/exd.12966
- Knafl, D., Thalhammer, F., & Vossen, M. G. (2017), In-vitro release pharmacokinetics of amikacin teicoplanin and polyhexanide in a platelet rich fibrin layer (PRF) a laboratory evaluation of a modern, autologous wound treatment, PLoS One e, 12(7), e0181090, https://doi.org/10.1371/journal.pone.0181090
- Tohidnezhad, M., Varoga, D., Podschun, R., Wruck, C. J., Seekamp, A., Brandenburg, L., Pufe, T., & Lippross, S. (2011). Thrombocytes are effectors of the innate immune system releasing human beta defensin-3. Injury-International Journal of the Care of the Injured, 42(7), 682–686. https://doi.org/10.1016/j.injury.2010.12.010
- Kjaergard, H. K., Velada, J. L., Pedersen, J. H., Fleron, H., & Hollingsbee, D. (2000), Comparative kinetics of polymerisation of three fibrin sealant and influence on thiming of tissue adhesion, Thrombosis Research , 98(2), 221–228, https://doi.org/10.1016/s0049-3848(99)00234-0
- Sciuto, A., Merola, G., De Palma, G. D., Sodo, M., Pirozzi, F., Bracale, U., & Bracale, U. (2018). Predictive factors for anastomotic leakage after laparoscopic colorectal surgery. World Journal of Gastroenterology, 24(21), 2247–2260. https://doi.org/10.3748/wjg.v24.i21.2247
- DCCG. (2023, October 3). Danish Colorectal Cancer Group Annual Report 2021. https://dccg.dk/arsrapporter/
- RKKP. (2023, November 28). Danish EsophagoGastric Cancer Group database – Annual report 2021 RKKP’S Knowledge Center https://www.rkkp.dk/
- Turrentine, F. E., Denlinger, C. E., Simpson, V. B., Garwood, R. A., Guerlain, S., Agrawal, A., Friel, C. M., LaPar, D. J., Stukenborg, G. J., & Jones, R. S. (2015). Morbidity, mortality, cost, and survival estimates of gastrointestinal anastomotic leaks. Journal of the American College of Surgeons, 220(2), 195–206. https://doi.org/10.1016/j.jamcollsurg.2014.11.002
- Frasson, M., Battersby, N., Bhangu, A., Hervás, D., El‐Hussuna, A., Gallo, G., Pata, F., Pinkney, T., Poškus, T., Singh, B., Investigators, L., Bernstein, I., Sunesen, K. G., Leunbach, J., Thorlacius-Ussing, O., & Ovesen, A. U. (2020). Predictors for anastomotic leak, postoperative complications, and mortality after right colectomy for cancer: results from an international snapshot audit. Diseases of the Colon & Rectum, 63(5), 606–618. https://doi.org/10.1097/dcr.0000000000001590
- La Regina, D., Di Giuseppe, M., Lucchelli, M., Saporito, A., Boni, L., Efthymiou, C. A., Cafarotti, S., Marengo, M., & Mongelli, F. (2018). Financial impact of anastomotic leakage in colorectal surgery. Journal of Gastrointestinal Surgery, 23(3), 580–586. https://doi.org/10.1007/s11605-018-3954-z
- Enodien, B., Maurer, A., Ochs, V., Bachmann, M. F., Gripp, M., Frey, D. M., & Taha, A. (2022). The Effects of Anastomotic Leaks on the Net Revenue from Colon Surgery. International Journal of Environmental Research and Public Health, 19(15), 9426. https://doi.org/10.3390/ijerph19159426
- ClinicalTrials.gov. (n.d.). https://clinicaltrials.gov/ct2/show/NCT05174910
