Co-delivering drugs, stem cells etc. with the Vivostat® Fibrin Sealant or Vivostat PRF® solutions offers the surgeon and the patient a number of benefits:

  • Topical application
  • Targeting affected/desired ares
  • Possible higher local dose
  • Possible lower systemic impact
  • Improved compliance

No Thrombin

Moreover, no thrombin is added to Vivostat® Fibrin Sealant and Vivostat PRF® (unlike most other sealants and PRP products). This is beneficial to the Co-Delivery system as thrombin activation been shown to have negative effect on cell survival1.

The effect of the Fibrin membrane 

The fibrin membrane found in both Vivostat® Fibrin Sealant and Vivostat PRF® has, furthermore, been shown postpone the degradation process of the substance. This means that the fibrin membrane ensures a slow and sustained release of the substance offering a prolonged effect2.

Documented slow release of antibiotics

An in-vitro study has documented a slow release of active antibiotics in combination with Vivostat PRF®. The antibiotics include Teicoplanin and amikacin.

Read about the study here.

 

1) High thrombin concentrations in fibrin sealants induce apoptosis in human keratinocytes. Gugerell et al. · Journal of Biomedical Materials Research Part A 2012; May:100(5):1239-47

2) Intrapleural topical application of cisplatin with the surgical carrier Vivostat increases the local drug concentration in an immune-competent rat model with malignant pleuromesothelioma. Lardinois et al. · J Thorac Cardiovasc Surg 2006;131:697-703